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“Lectins are proteins that can bind the sugar molecule structure on lipids or proteins such as the spike protein. Our idea is to harness this property to develop a drug to combat COVID-19 disease.”
What you see in the video, he said, is the single spike (the large bright object) and lectins (smaller fast-moving objects).
It was shot at 303 milliseconds per frame over an area of the virus measuring 100 X 100 nm² (nanometres are one-billionth of a metre), using something called atomic force microscopy at the University of Linz, Austria.
“This is what it looks like in real time when the spike binds to something,” Penninger said. “Very few people have this microscope, so it was great to hook up with people who do some really cool stuff with cool technologies.”
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Potential ‘Achilles’ heel’ of SARS-CoV-2 virus captured on video
Proteins known as lectins can bind to the spike protein on the SARS-CoV-2 virus and prevent it from accessing human cells, an international team of researchers led by the University of British Columbia’s Dr. Josef Penninger has demonstrated.
They have captured the action on the pathogen’s spike protein via video.
“Lectins are proteins that can bind the sugar molecule structure on lipids or proteins such as the spike protein,” explains Dr. Penninger, director of the Life Sciences Institute in Vancouver. “Our idea is to harness this property to develop a drug to combat COVID-19 disease.”
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