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IMAGE: Provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. view more
Credit: Mary Ann Liebert Inc., publishers
New Rochelle, NY, December 10, 2020 The phenomenon of AAV capsid-promoter interaction recently seen in the rat central nervous system has now been shown to occur in the non-human primate brain. This interaction can directly determine cell-specific transgene expression, as described in
Human Gene Therapy. Click here to read the full-text article free on the
Human Gene Therapy website through January 10, 2021.
An adeno-associated virus (AAV) contains a single-stranded DNA genome encapsulated in a capsid comprised of three structural proteins.
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IMAGE: A team led by Nevan Krogan at Gladstone and UCSF has demonstrated that a large-scale and systematic genetic approach can indeed yield reliable and detailed information on the structure of. view more
Credit: QBI, UCSF
SAN FRANCISCO, CA December 10, 2020 One of biologists most vexing tasks is figuring out how proteins, the molecules that carry the brunt of a cell s work, do their job. Each protein has a variety of knobs, folds, and clefts on its surface that dictate what it can do. Scientists can visualize these features fairly easily on individual proteins. But proteins don t act alone, and scientists also need to know the shape and composition the structure, as they call it of the complexes that proteins form when working together.