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The new reference dataset includes 64 assembled genomes representing 25 different human populations from across the globe.
Exactly 20 years after the successful completion of the Human Genome Project, an international group of researchers, the Human Genome Structural Variation Consortium, has now sequenced 64 human genomes at high resolution. This reference data includes individuals from all over the world to better capture the genetic diversity of the human species. Among other applications, the work enables population-specific studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation, as the 65 authors report in the Feb. 26 issue of the scientific journal Science.
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Study: Interbacterial toxins may contribute to bacterial genetic diversity
A toxin produced by bacteria as a defense mechanism causes mutations in target bacteria that could help them survive, according to a study published today in
eLife.
The finding suggests that competitive encounters between bacterial cells could have profound consequences on the evolution of bacterial populations.
When bacterial cells come into contact, they often produce toxins as a defense mechanism. Although it is known that the bacteria producing these toxins have a competitive advantage, exactly how the toxins affect the recipient cells is less clear.
Undergoing intoxication is not always detrimental for cells - there are scenarios in which encountering a toxin could provide a benefit, such as generating antibiotic resistance. We wanted to study the effects of a toxin that alters DNA beyond that of cell death and see how it impacts the surviving recipient cells it targets.
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