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London School of Hygiene & Tropical Medicine Link identified between HIV drug and skeletal deficits in Zimbabwean children Children growing up with HIV infection have concerning deficits in skeletal strength which become more apparent towards the end of pubertal growth, finds the new research in The Lancet Child and Adolescent Health. In the largest study to date to investigate the link between HIV and skeletal health in children, the researchers found a potential association between these skeletal deficits and the first-line antiretroviral-HIV drug, tenofovir disproxil fumarate (TDF), which is widely used across sub-Saharan Africa. The research was carried out by the London School of Hygiene & Tropical Medicine (LSHTM), the University of Zimbabwe, the University of Bristol and the Biomedical Training and Research Institute in Zimbabwe. The findings raise concerns for the long-term impact of this drug on the skeletal health of adolescents across the region, as they transition int

Mashonaland eastRuramayi rukuniRashida ferrandCelia gregsonLondon school of hygiene tropical medicineWellcome trust phResearch instituteProfessor of clinical epidemiology at bristol universityUniversity of zimbabweProfessor of international healthUniversity of bristolLancet childLondon schoolTropical medicineBiomedical trainingSaharan africa