Using ultrasound and RNA-loaded nanoparticles to deliver potent medicine to brain tumors
RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality. This rapidly expanding class of therapeutics are cost-effective, fairly easy to manufacture, and able to go where no drug has gone before, reaching previously undruggable pathways.
Mostly.
So far, these promising drugs haven t been very useful in getting through to the well-protected brain to treat tumors or other maladies.
Now a multi-institutional team of researchers, led by Costas Arvanitis at the Georgia Institute of Technology and Emory University, has figured out a way: using ultrasound and RNA-loaded nanoparticles to get through the protective blood-brain barrier and deliver potent medicine to brain tumors.
Georgia Institute of Technology
RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality. This rapidly expanding class of therapeutics are cost-effective, fairly easy to manufacture, and able to go where no drug has gone before, reaching previously undruggable pathways.
Mostly.
So far, these promising drugs haven’t been very useful in getting through to the well-protected brain to treat tumors or other maladies.
Now a multi-institutional team of researchers, led by Costas Arvanitis at the Georgia Institute of Technology and Emory University, has figured out a way: using ultrasound and RNA-loaded nanoparticles to get through the protective blood-brain barrier and deliver potent medicine to brain tumors.
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IMAGE: Georgia Tech Mechanical Engineering Ph.D. student Yutong Guo (left) and her mentor, assistant professor Costas Arvanitis, have developed a way to use ultrasonics to treat brain disease. view more
Credit: Ashley Ritchey, Georgia Tech
RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality. This rapidly expanding class of therapeutics are cost-effective, fairly easy to manufacture, and able to go where no drug has gone before, reaching previously undruggable pathways.
Mostly.
So far, these promising drugs haven t been very useful in getting through to the well-protected brain to treat tumors or other maladies.
BLOG: Cloud-Based Imaging Platform Streamlines Workflows, Ensures Data De-Identification and Improves Collaboration in Clinical Trials
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Medical imaging, an often-overlooked piece of the puzzle in establishing a holistic patient health record, plays a fundamental role in the design of research studies and clinical trials. Imaging workflows, however, can present various challenges because imaging traditionally has been exchanged on CDs that are uploaded and mailed. From obtaining, identifying and uploading the images, to reading, analyzing and archiving them correctly the entire process is error-prone and often delays progress in trials due to inconsistent or slow imaging data input.
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In this age of skepticism, it’s reassuring to know that at least two cherished American myths – Horatio Alger s model of the self-made man and the image of the visionary inventor tinkering in his garage – still exist in the person of Dr. Thomas J. Fogarty. This renowned Irish-American heart surgeon, who started his inventing career as a boy in Cincinnati, is responsible for devices that have revolutionized cardiovascular surgery over the past four decades. His products are credited with making such surgery less threatening to the lives of tens of millions of people.
Fogarty’s first medical invention, the Fogarty… Arterial