A former Arlington doctor was recently sentenced to three years in prison after a Virginia jury found him guilty of fetal murder. According to the court documents, Sikander Imran slipped an abortion pill inside his girlfriend’s tea to induce labor.
Arlington Doctor Could Be Deported To Pakistan
Brooke Fiske, the woman romantically involved with Imran told her story to a local … [Read more.]
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Jan. 17, 2021
The fall of the great city of Ugarit and rise of towns along the coasts of today’s Israel and Lebanon had been thought to date after the empires around the Mediterranean collapsed 3,200 years ago. Now the discovery of a significant number of Canaanite jars in the Mycenaean city of Tiryns dating to well before the collapse indicates otherwise.
As the ancient civilizations around the Mediterranean arose, they not only warred on one another, they traded with each other too. Until the still-enigmatic large-scale collapse of civilizations around the Mediterranean in the 13th century B.C.E., Ugarit in today’s Syria had been believed to be the main trading partner across the sea for the Aegean kingdoms Tiryns and Mycenae.
Expert Insight: Urinary NMR diagnostics for inborn errors of metabolism using rule-based interpretation (for research use only)
Watch this on-demand webinar to learn about the potential of computer-assisted interpretation and linking disease markers identified by NMR to the metagene database
14 Jan 2021
Prof. Dr. med. Friedrich Trefz and Dr. Georg Frauendienst-Egger
Inborn errors of metabolism are rare diseases that often provide a typical pattern of elevated metabolites in biological fluids like urine, blood (plasma or serum), or cerebrospinal fluid. More than 1,000 different diseases are known. Because of the different chemical classes of those metabolites, the most used methods are gas chromatography-mass spectrometry (GC/MS), liquid chromatography-mass spectrometry (LC/MS), and other chromatographic methods. However, by using NMR analysis, which is a highly reproducible and quantitative method, it is possible to quantify simultaneously metabolites from a wide range of differ
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray crystallography and cryo-electron microscopy. Based on the structures, we engineered multivalent nanobodies with more than 100-fold improved neutralizing activity than monovalent nanobodies. Biparatopic nanobody fusions suppressed the emergence of escape mutants. Several nanobody constructs neutralized through receptor-binding competition, while other monovalent and biparatopic nanobodies triggered aberrant activation of the spike fusion machinery. These premature conformational changes in the spike protein forestalled productive fusion, and rendered the virions non-infectious.