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LEO Pharma initiates head-to-head study to evaluate brodalumab vs guselkumab in adult patients with moderate-to-severe psoriasis who have inadequate response to ustekinumab

Posted on 7466 LEO Pharma A/S – a global leader in medical dermatology – announced today that the first patient has been screened in the first head-to-head clinical trial to evaluate brodalumab (marketed in the European Union as Kyntheum ®) compared with guselkumab (marketed globally as Tremfya ®) in adult patients with moderate-to-severe plaque psoriasis who have an inadequate response to ustekinumab (marketed globally as Stelara ®) treatment. Per Sproegel (Photo: Business Wire) The COBRA (COmparing BRodalumab And guselkumab in ustekinumab inadequate responders) clinical trial is a randomized, double-blind, parallel-group, multinational study. The primary study endpoint is the proportion of patients who achieve PASI 100 (100% skin clearance) at week 16. The study further includes several secondary and exploratory endpoints, including the key secondary endpoint of time to PASI 100 response while on treatment

Raman Spectroscopy may Aid Early Oral Cancer Diagnosis

Raman Spectroscopy may Aid Early Oral Cancer Diagnosis by Colleen Fleiss on  January 13, 2021 at 11:37 PM Raman spectroscopy showed promise for early detection of oral squamous cell carcinoma (OSCC), said researchers. OSCC is the most prevalent type of oral cancer and ranks among the most common cancers diagnosed worldwide. Although effective treatments are available, the cancer is often not detected until a late stage, resulting in overall poor prognosis. Raman spectroscopy is not only label-free and non-invasive, but it can potentially be used in ambient light conditions, says research team leader Levi Matthies from University Medical Center Hamburg-Eppendorf in Germany. This makes it promising for use as a potential screening tool in the dentist s office.

Raman spectroscopy shows promise for diagnosing oral cancer

 E-Mail IMAGE: A new study shows that Raman spectroscopy could aid in early detection of oral squamous cell carcinoma. The work was performed with a compact portable Raman sensor designed by the. view more  Credit: Levi Matthies, University Medical Center Hamburg-Eppendorf WASHINGTON In a new study, researchers show that a light-based analytical technique known as Raman spectroscopy could aid in early detection of oral squamous cell carcinoma (OSCC). OSCC is the most prevalent type of oral cancer and ranks among the most common cancers diagnosed worldwide. Although effective treatments are available, the cancer is often not detected until a late stage, resulting in overall poor prognosis.

Invisible Stem Cells Evade Natural Killer Cells Using Immune Off-Switch

Image by National Institutes of Allergy and Infectious Diseases UC San Francisco scientists have discovered a new way to control the immune system’s “natural killer” (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection. The findings could also be used to enhance the ability of cancer immunotherapies to detect and destroy lurking tumors.  The study, published Jan. 8, 2021, in the Journal of Experimental Medicine, addresses a major challenge for the field of regenerative medicine, said lead author Tobias Deuse, MD, the Julien I.E. Hoffman, MD, Endowed Chair in Cardiac Surgery in the UCSF Department of Surgery. 

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