of The Church of Jesus Christ of Latter-day Saints.
As fast as the blood flows into the right atrium of President Spencer W. Kimball’s stopped heart, a tube pumps it out of his body and into a machine next to the operating table.
Dr. Russell M. Nelson peers down into the chest cavity. The room smells of cauterized blood vessels and arteries. Not long ago, this was unthinkable. Operating on a live heart was a medical sin when he entered medical school.
The blood streaming into the machine had been returning to President Kimball’s heart after a trip through his body. The machine takes over for the heart and lungs. An oxygenator strips out carbon dioxide and delivers oxygen. Then the heart-lung machine returns the blood to the aorta, which sends it coursing to his brain, fingers and toes.
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(Philadelphia, PA) - Like a failing fuel pump that causes a loss of engine power in a car, a diseased heart can take a serious toll on the body s performance. For some patients, tasks like walking up a flight of stairs or walking across a room eventually turn into exhausting endeavors. This is because, over time, regardless of the underlying cause, heart damage typically progresses, owing to a constant barrage of oxidative stress and toxic lipids that alter heart cell energetics and, ultimately, the ability of the heart to function normally.
Oxidative stress occurs when harmful oxygen-containing molecules outnumber helpful antioxidants, leading to damaging reactions with proteins, DNA, and other cell components. Now, in two new studies, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) show that in the heart, one molecule in particular, Kruppel-like factor (KLF)-5, single-handedly fuels both the generation of oxidizing molecules and the accumul
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