Shailendra Patel, MD, DPhil, director of the Division of Endocrinology, Diabetes and Metabolism, spoke with a journalist with Reuters Health about the.
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Inherited or transmitted gut microbes affect skeletal development in animals
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals bone mass, says a new study published today in
eLife.
The findings suggest that treatments which alter the gut microbiome could help improve bone structure or treat conditions that weaken bones, such as osteoporosis.
Genetics account for most of the variability in human bone density, but non-genetic factors such as gut microbes may also play a role. We wanted to investigate the influence of the microbiome on skeletal growth and bone mass development.
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(Philadelphia, PA) - Like a failing fuel pump that causes a loss of engine power in a car, a diseased heart can take a serious toll on the body s performance. For some patients, tasks like walking up a flight of stairs or walking across a room eventually turn into exhausting endeavors. This is because, over time, regardless of the underlying cause, heart damage typically progresses, owing to a constant barrage of oxidative stress and toxic lipids that alter heart cell energetics and, ultimately, the ability of the heart to function normally.
Oxidative stress occurs when harmful oxygen-containing molecules outnumber helpful antioxidants, leading to damaging reactions with proteins, DNA, and other cell components. Now, in two new studies, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) show that in the heart, one molecule in particular, Kruppel-like factor (KLF)-5, single-handedly fuels both the generation of oxidizing molecules and the accumul
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Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals bone mass, says a new study published today in
eLife.
The findings suggest that treatments which alter the gut microbiome could help improve bone structure or treat conditions that weaken bones, such as osteoporosis. Genetics account for most of the variability in human bone density, but non-genetic factors such as gut microbes may also play a role, says lead author Abdul Malik Tyagi, Assistant Staff Scientist at the Division of Endocrinology, Metabolism, and Lipids at Emory Microbiome Research Center, Emory University, Georgia, US. We wanted to investigate the influence of the microbiome on skeletal growth and bone mass development.