Giving chemotherapy in the morning can extend survival of glioblastoma patients
An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study from Washington University in St. Louis suggests that a minor adjustment to the current standard treatment -; giving chemotherapy in the morning rather than the evening -; could add a few months to patients survival.
The study appears online in the journal Neuro-Oncology Advances.
Average overall survival for all patients in the study was about 15 months after diagnosis. Those receiving the chemotherapy drug temozolomide in the morning had an average overall survival of about 17 months post diagnosis, compared with an average overall survival of about 13½ months for those taking the drug in the evening, a statistically
Study indicates timing of chemotherapy may improve treatment for glioblastoma - World News
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Chemo for glioblastoma may work better in morning than evening | The Source | Washington University in St Louis
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Projection of cancer screening on metastasis: A prostate cancer case study
From the Etzioni Group, Public Health Sciences Division March 15, 2021 • By Coco Davis / Fred Hutchinson Cancer Research Center
One of the main purposes of cancer screening is to detect localized tumors early to reduce cancer mortality. The belief or prediction that early detection will decrease the likelihood of advanced-stage cancer is called “stage shift”. Unfortunately, stage shift doesn’t consider progressive cases after diagnosis. Additionally, the diagnosis of advanced-stage cancer with screening does not always reduce disease-specific deaths. The reduction of advanced-stage cases at diagnosis will become organ-confined cases and increase the number of cases eligible for metastasis. Also, progressive cases may reduce the incidence of metastatic disease at diagnosis, resulting in the same number of metastatic cases in a screened and non-screened group.