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Date Time Molecular Imaging Determines Effectiveness of Novel Metastatic Breast Cancer Treatment Reston, VA-Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients who are resistant to hormonal therapy. According to research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) imaging using an imaging agent called 18F-fluoroestradiol can help to determine which patients could benefit from treatments that could spare them from unnecessary chemotherapy. Nearly two-thirds of invasive breast cancers are ER-positive, and endocrine therapy is the mainstay of treatment for these tumors because of its favorable toxicity profile and efficacy. Should cancer progress in these patients, however, salvage endocrine therapy with molecularly targeted agents or chemotherapy can help.

United statesCzech republicUniversity of pennsylvaniaFred hutchinson cancer research centerKennetha krohnHannahm lindenAlena novakova jiresovaFengting yanVijayakrishnak gadiBrendaf kurlandDavida mankoffErink schubertJenniferm spechtJulier gralowJournal of nuclear medicineDepartment of radiology