Clinical study identifies genetic changes in head-neck cancer, association with immunotherapy resistance
Clinical study identifies genetic changes in head-neck cancer, association with immunotherapy resistance
Last Updated: Tue, Apr 27th, 2021, 10:20:08hrs
Washington [US], April 27 (ANI): A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy. Through a series of surprises, we followed clues that focused more and more tightly on specific genetic imbalances and their role in the effects of specific immune components in tumour development, said co-principal investigator Webster Cavenee, PhD, Distinguished Professor Emeritus at the University of California San Diego School of Medicine.
Dr. Sherman James is a native of Hartsville, S.C. He graduated from Butler High School, in Hartsville, in 1960. He was Valedictorian of his class, and president of the student body.
A social epidemiologist, Dr. James is the Susan B. King Distinguished Professor Emeritus of Public Policy at Duke University. He taught at Duke from 2003-2014. Before this, he taught at the University of North Carolina – Chapel Hill (1973-1989), and the University of Michigan – Ann Arbor (1989-2003). Dr. James earned an AB degree in Psychology and Philosophy, in 1964, from Talladega College in Alabama; he earned a PhD degree in Social Psychology, in 1973, from Washington University in St. Louis.
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A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy. Through a series of surprises, we followed clues that focused more and more tightly on specific genetic imbalances and their role in the effects of specific immune components in tumor development, said co-principal investigator Webster Cavenee, PhD, Distinguished Professor Emeritus at University of California San Diego School of Medicine. The genetic abnormalities we identified drive changes in the immune cell composition of the tumors that, in turn, dictates responsiveness to standard of care immune checkpoint inhibitors.
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