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Ethics of genetically reconstituting oocytes Appeared in BioNews 1085 In the 16 December issue of Nature, researchers reported that the addition of eight transcription factors to pluripotent stem cells converted them into a primary oocyte-like cell. While these cells did not undergo normal meiosis, and therefore did not have the correct number of gamete chromosomes, they could be fertilised by sperm to initiate partial embryonic development, with some even progressing to an eight-cell morula stage. This achievement enhances our understanding of oocyte maturation and may have useful clinical applications in reproductive technologies. In mitochondrial donation, for instance, an oocyte is obtained from a woman with genetically defective mitochondria. The nucleus from this oocyte is removed and put into an enucleated donor oocyte obtained from a woman with healthy mitochondria. This transcription-stem cell-based approach could one day be used to generate enucleated oocytes (cytoplasts

Johnd loikeHumanities program at new york medical collegeUniversity systemTouro collegeBiomedical ethicsHumanities programNew york medical collegeமனிதநேயம் ப்ரோக்ர்யாம் இல் புதியது யார்க் மருத்துவ கல்லூரிபல்கலைக்கழகம் அமைப்புடூரோ கல்லூரிஉயிர் மருத்துவ நெறிமுறைகள்மனிதநேயம் ப்ரோக்ர்யாம்புதியது யார்க் மருத்துவ கல்லூரி