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The study – led by researchers at the Cancer Research UK Beatson Institute at the University of Glasgow and the University of Helsinki, and published today in Nature – provides crucial insight into the early stages of the disease, and also identifies a molecule that’s a ‘key player’ in this process, information which could lead to new ways to prevent tumour development in high-risk individuals.
The study, done in mouse models, looked at APC, one of the most commonly mutated genes in colorectal tumours, to identify how APC mutant cells compete with neighbouring normal cells. The researchers discovered the involvement of a molecule called NOTUM in the development of the disease. They hope that one day it will be possible to deploy NOTUM inhibitors, some of which are currently under development, as a possible early treatment.
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