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New understanding of physical properties of chromatin may show how genome is encoded and decoded

New understanding of physical properties of chromatin may show how genome is encoded and decoded University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid? In a study published in the journal Cell, the research team, led by Department of Oncology professor Michael Hendzel and collaborator Jeffrey Hansen from Colorado State University, found that chromatin is neither a solid nor a liquid, but something more like a gel.

Discovery finds cellular building block acts as a gel, not liquid as previously believed

Discovery finds cellular building block acts as a gel, not liquid as previously believed ANI | Updated: Dec 18, 2020 23:44 IST Washington [US], December 18 (ANI): In a recent study, the research team of Colorado State University, found that chromatin is neither a solid nor a liquid, but something more of a gel. The study was led by Department of Oncology professor Michael Hendzel and collaborator Jeffrey Hansen. Previously, fields such as biochemistry operated under the assumption that chromatin and other elements of the nucleus operated in a liquid state, Hendzel said. This new understanding of the physical properties of chromatin challenges that idea, and could lead to a more accurate understanding of how the genome is encoded and decoded.

Discovery finds a cellular building block acts as a gel, not liquid as previously believed

 E-Mail University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid? Cell, the research team, led by Department of Oncology professor Michael Hendzel and collaborator Jeffrey Hansen from Colorado State University, found that chromatin is neither a solid nor a liquid, but something more like a gel. Previously, fields such as biochemistry operated under the assumption that chromatin and other elements of the nucleus operated in a liquid state, Hendzel said. This new understanding of the physical properties of chromatin challenges that idea, and could lead to a more accurate understanding of how the genome is encoded and decoded.

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