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Study reveals new insights into the effects of chemotherapy on tumor microenvironment

Exercise benefit in breast cancer linked to improved immune responses

Physical exercise increases levels of cancer-fighting immune cells in animal models of breast cancer and slows the growth of tumors. In addition to lowering risk of developing cancer, structured exercise programs could help improve therapy for females with existing breast tumors. Exercise may also significantly improve treatment of breast cancer with immunotherapy drugs.

The impact of chemotherapy on immune cells in the tumor microenvironment

The impact of chemotherapy on immune cells in the tumor microenvironment
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Sequential treatment with immunotherapy and checkpoint inhibitors prolongs anti-tumor activity

 E-Mail TAMPA, Fla. - Advanced melanoma is one of the deadliest types of cancer, with a 5-year survival rate of only 27% for patients with distant metastases. Recent advances in targeted therapies and immunotherapies have greatly improved patient prognosis; however, many patients eventually develop resistance and disease recurrence. Researchers at Moffitt Cancer Center are investigating how to combine and sequence new therapies to improve survival. In a new article published in Cancer Immunology Research, the Moffitt team shows that sequential administration of immunotherapy followed by targeted therapy prolongs anti-tumor responses in preclinical models and may be a potential treatment option for patients.

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