Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments.
The progression of cancer and autoimmune diseases are both characterised by intense inflammation and both diseases recruit immune cells to quell the escalating inflammation. In cancer, the recruitment of these cells, primarily regulatory (suppressor) T cells, attempt to resolve the ongoing inflammation with the result of turning down anticancer immunity. In autoimmune diseases, the constant stimulation of inflammation (immune reaction against the body’s own tissues) overwhelms the regulatory T cells. In both diseases other immune cells can also suppress immunity, with similar results as regulatory T cells. Furthermore, the biochemical pathways that regulate immune cell function are the same in both diseases.
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Cerecor Announces First Patient Dosed in a Phase 1b Clinical Trial of CERC-007 for the Treatment of Relapsed or Refractory Multiple Myeloma
Cerecor Announces First Patient Dosed in a Phase 1b Clinical Trial of CERC-007 for the Treatment of Relapsed or Refractory Multiple Myeloma
ROCKVILLE, Md. and CHESTERBROOK, Pa., Dec. 16, 2020 Cerecor Inc. (NASDAQ: CERC), a biopharmaceutical company focused on becoming a leader in development and commercialization of treatments for rare and orphan diseases, today announced that it has dosed its first patient in a Phase 1b clinical trial of CERC-007. CERC-007 is a high affinity, fully human anti-IL-18 monoclonal antibody (mAb) being developed for patients with relapsed or refractory multiple myeloma (MM). The study will determine the recommended Phase 2 dose, safety and preliminary efficacy of CERC-007. The Company anticipates initial data to be reported in the first quarter of 2021.
10 Questions About Advanced Colon Cancer Treatment
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You’ve gotten your initial diagnosis, which already was a shock. Now your doctor has more potentially bad news your cancer has spread and you are among the 22% of patients who has stage 4, or advanced, colon cancer. Now what? You’ll probably have a lot of questions about your treatment plan and what you can expect. Here are some reassuring answers.
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What does stage 4 cancer really mean?
“The way that I approach thinking about staging is if you see cancer outside of the colon, that s metastatic disease, and that’s stage four,” says Leah Biller, M.D., an oncologist at Dana-Farber’s Gastrointestinal Cancer Treatment Center in Boston. Doctors arrive at the number by doing imaging tests (CT scans or, sometimes, MRIs or PET scans) as well as surgically removing the tumor. If the scans show that there’s cancer in other parts of your body your lungs, your liver or in the lymph nodes outside the colon, that’