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PHILADELPHIA Black adults are more likely than other groups to develop Alzheimer s disease or related disorders but are poorly represented in Alzheimer s disease research, including recent clinical trials. This health disparity illustrates how Black individuals can benefit from advances in the field if they had access.
This week, the Pennsylvania Department of Health s Commonwealth Universal Research Enhancement (CURE) program announced it will award a $3.5 million grant to Penn Medicine researchers and community partners to address the underrepresentation of Black adults in Alzheimer s Disease research. The grant supports the Aging Brain Cohort Dedicated to Diversity (ABCD2) study, a research and training initiative led by David Wolk, MD, a professor of Neurology in the Perelman School of Medicine at the University of Pennsylvania. Wolk is also the incoming director of the Alzheimer s Disease Research Center, and co-director of the Penn Memory Center.
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Need another reason to get vaccinated? It prevents sepsis, the condition that makes COVID-19 deadly
Marie McCullough, The Philadelphia Inquirer
April 28, 2021
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Increase your arm’s blood flow post-vaccine and swing it around.FotoDuets/Getty Images/iStockphoto
PHILADELPHIA The reason severe COVID-19 is so deadly is that it unleashes a condition called sepsis.
Sepsis occurs when an abnormal immune response to an infection damages the body’s own tissues, leading to organ failure.
Of the 26,266 people who were hospitalized with COVID-19 in Pennsylvania in the first seven months of the pandemic, about 8,000, or 31%, also were diagnosed with sepsis, according to a new report from the Pennsylvania Health Care Cost Containment Council (PHC4).
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PHILADELPHIA Art appreciation is considered essential to human experience. While taste in art varies depending on the individual, cognitive neuroscience can provide clues about how viewing art affects our neural systems, and evaluate how these systems inform our valuation of art. For instance, one study shows that viewing art activates motor areas, both in clear representations of movement, like Adam and Eve in Michelangelo s Expulsion from Paradise, and in implied movement through brush strokes, like in Franz Kline s gestural paintings.
Altered neural functioning, like that experienced in patients with Parkinson s disease, changes the way art is both perceived and valued, according to a study published recently in The
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PHILADELPHIA Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors. Now an international team including researchers from the Perelman School of Medicine at the University of Pennsylvania has illuminated one way in which the piperlongumine works in animal models and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer.
The researchers, whose findings were published this month in
ACS Central Science, showed in detail how piperlongumine binds to and hinders the activity of a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression. The scientists found that piperlongumine treatment radically shrank glioblastoma tumors and extended life in two mouse models of this cancer, and also selectively destroyed glioblastoma cells taken from human patients.