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Probing deeper into tumor tissues
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$7 million to advance cardiovascular research
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A) Distribution of observed first-positive viral loads for 25,381 subjects according to clinical status (6110 PAMS, 9519 Hospitalised, 9752 Other) and age group. (
B) Age-viral load association with observed viral loads and confidence intervals as circles (with size indicating subject count) with vertical lines, and model-predicted viral loads and credible intervals as a black roughly-horizontal line with grey shading. (
C) Overlapping age histograms according to subject clinical status. Because inclusion in the study required a positive RT-PCR test result, and testing is in many cases symptom-dependent, the study may have a proportion of PAMS cases that differs from the proportion in the general population.
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IMAGE: The confocal microscope image shows the patient s primary muscle stem cells, which have continued to proliferate after repair of the mutation using base editing . view more
Credit: Spuler Lab, ECRC
Muscle stem cells enable our muscle to build up and regenerate over a lifetime through exercise. But if certain muscle genes are mutated, the opposite occurs. In patients suffering from muscular dystrophy, the skeletal muscle already starts to weaken in childhood. Suddenly, these children are no longer able to run, play the piano or climb the stairs, and often they are dependent on a wheelchair by the age of 15. Currently, no therapy for this condition exists.
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IMAGE: Increased sodium concentrations in the blood cause the mitochondria - the power plants of the cells - to temporarily produce less ATP. view more
Credit: Felix Petermann, MDC
For many of us, adding salt to a meal is a perfectly normal thing to do. We don t really think about it. But actually, we should. As well as raising our blood pressure, too much salt can severely disrupt the energy balance in immune cells and stop them from working properly.
Back in 2015, the research group led by Professor Dominik Müller of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Experimental and Clinical Research Center (ECRC) found that elevated sodium concentrations in the blood affect both the activation and the function of patrolling monocytes, which are the precursors to macrophages. But we didn t know exactly what was happening in the cells, says Dr. Sabrina Geisberger of the Berlin Institute for Medical Systems Biology (
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