6 Some studies revealed that lncRNAs are related to the development and progression of DN.
7–9 For example, lncRNA MALAT1 can regulate renal tubular epithelial pyroptosis by modulating miR-23c targeting of ELAVL1 in DN.
10 LncRNA Tug1 can regulate mitochondrial bioenergetics in DN.
3 Moreover, lncRNA PVT1 (PVT1) has been shown to be involved in accelerating the progression of DN by promoting ECM accumulation and increasing expression of fibronectin 1 (FN1).
11 However, the underlying mechanism of PVT1 on diabetic nephropathy remains unclear.
MicroRNAs (miRNAs) are non-coding RNAs with 20–30 nucleotides that can bind to mRNA to regulate its protein expression.
12 Previous reports indicated that miRNA-325-3p can suppress inflammation and fibrosis in the progression of DN.
Knowing DNA Repair Toolkit to Chart Cancer Evolution by Angela Mohan on February 18, 2021 at 3:40 PM
Deficiencies in DNA repair pathways increase the instability of the genes, and this causes cancer to develop.
Therefore, detailed knowledge of how DNA repair pathways participate in this process is crucial for tracking tumor progression, understanding the emergence of drug resistance, and developing efficient therapeutic interventions.
To this end, a group of scientists from China examined five critical DNA repair pathways and their impact on cancer evolution by reviewing the findings of the latest published research. So, it is not surprising that particularly defective DNA repair pathways are associated with specific cancers.
Combining lipid-lowering drugs and lifestyle interventions may yield greatest heart-protecting benefits
Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife.
Having a healthy lifestyle has long been associated with a lower risk of developing heart disease. The new study provides more detailed information on how healthy lifestyles improve cholesterol, and suggests that combining cholesterol-lowering medications and lifestyle interventions may yield the greatest benefits to heart health.
Cholesterol-lowering medications such as statins help reduce heart risks by lowering levels of low-density lipoprotein (LDL) cholesterol, the so-called bad cholesterol. Healthy lifestyle interventions, including exercising regularly, having a healthy diet, lowering alcohol consumption and maintaining a healthy weight, have also been shown to lower LDL as w
DNA repair pathways exist to correct molecular damage caused by internal and external factors. However, any damage to these pathways can result in the creation of tumors and specific types of cancers.
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IMAGE: Studying the intricacies of DNA repair mechanisms may help us understand cancer evolution better, and even provide us the weapons to fight cancer. view more
Credit: Cancer Biology & Medicine
The ongoing fight of science against cancer has made great strides, but cancer cells have not made it easy. The complexity of cancer cells and their adaptive evolutionary nature complicate the search for effective cures. Multiple DNA repair pathways in healthy cells typically work to rectify DNA damages caused by sources within the organism, like spontaneous DNA mutations, or from outside, like ultraviolet radiation.
But what happens when these pathways malfunction? It is known that deficiencies in these pathways increase the instability of the genes, and this causes cancer to develop. Therefore, detailed knowledge of how DNA repair pathways participate in this process is crucial for tracking tumor progression, understanding the emergence of drug resistance, and de