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Prototype Shows Promise As Approach to Countering Pancreatic Cancer News provided by Share this article Share this article NEW YORK, May 11, 2021 /PRNewswire/ A research team has designed a molecule with potential to interfere in a new way with altered proteins that cause abnormal growth in 35 percent of pancreatic cancers. Published online in Nature Communications on May 11, a new study found that a molecule called a monobody clings to cancer-causing versions of the KRAS protein and keeps them from transmitting their signals. Changes in the DNA of the KRAS gene – which encodes a molecular switch that toggles between active and inactive states to regulate growth – cause the related protein to become stuck in the on mode. Cells with such mutations continually multiply and give rise to cancer.

United statesCarmine fedeleSteven tsaiYingkai zhangGregory williamsKai wen tengJohn obryanAkiko koideShohei koideBenjamin neelXuben houTakamitsu hattoriNational institutes of healthLangone health perlmutter cancer centerDepartment of biochemistryDepartment of cell