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Scientists find mechanism linking neurodegenerative diseases with traumatic brain injury

Scientists find mechanism for neurodegenerative diseases

This Links TBI to Neurodegenerative Disease, Scientists Say

Study reveals potential mechanism for how traumatic brain injury leads to neurodegenerative diseases

Study reveals potential mechanism for how traumatic brain injury leads to neurodegenerative diseases Scientists have revealed a potential mechanism for how traumatic brain injury leads to neurodegenerative diseases, according to a study in fruit flies, and rat and human brain tissue, published today in eLife. The results could aid the development of treatments that halt the progression of cell damage after brain injury, which can otherwise lead to neurological diseases such as amyotrophic lateral sclerosis (ALS), and Alzheimer s and Parkinson s disease. Repeated head trauma is linked to a progressive neurodegenerative syndrome called chronic traumatic encephalopathy (CTE). Postmortem tissues from patients with CTE show dysfunctional levels of a molecule called TDP-43, which is also found in ALS, Alzheimer s disease and frontotemporal dementia.

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