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Credit: University of Bath Scientists from the UK s University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralise these enzymes. Many racemases and epimerases perform vital roles in human and animal cells, and in disease-causing organisms. They facilitate proper nerve function, the degradation of toxic substances, the formation of bacterial cell walls and the conversion of certain drugs into their active form (the best known conversion is seen with ibuprofen, which is taken as a mixture of isomers and converted in the liver to the active S-isomer). But while normal levels of racemase and epimerase function are generally beneficial, increased levels can be harmful. Because of this, there is considerable interest in

United kingdomSimon grievesonTim woodmanAmit nathubhaiMaksims yevglevskisMatthew lloydUnited kingdom university of bathChemical societyProfessor tony james department of chemistryProfessor mike threadgill department of pharmacy pharmacologyProstate cancer unitedProstate cancer united kingdomDrs lloydProfessor mike threadgillProfessor tony jamesஒன்றுபட்டது கிஂக்டம்