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German shares open 1 70 pct lower
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VFMCRP and ChemoCentryx Provide Topline Results From ACCOLADE Trial of Avacopan in C3 Glomerulopathy Including Improved Estimated Glomerular Filtration Rate (eGFR)
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(2)
As in ANCA vasculitis, avacopan demonstrated statistically significant improvement in renal function as measured by eGFR compared to placebo over 26 weeks of blinded treatment
The change from baseline to week 26 in C3 glomerulopathy histologic index (C3G HI) for disease activity (primary endpoint) was not statistically different between the two treatment groups, while the C3G HI for disease chronicity (measuring progression of fibrosis) shows significant benefit for avacopan versus placebo
Avacopan safe and well tolerated in C3G patients
ChemoCentryx and VFMCRP plan to discuss registration pathway with regulatory agencies in US and EU
Regulatory News:
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European Markets Close Sharply Lower On Virus Jitters, Brexit Uncertainty
A lack of progress in Brexit talks hurt as well.
In virus news, a fast-spreading new coronavirus strain shut down much of the United Kingdom and disrupted international freight.
More than 16 million Britons are now required to stay at home as a full lockdown came into force in London and the southeast of England.
The new variant of the virus, which is thought to be up to 70% more transmissible than the original strain of the disease, has reportedly been identified in Denmark, the Netherlands and Australia.
On the Brexit front, a deadlock of fishing rights in Britain s waters continued to stall negotiations about a trade deal.
German shares open 1 70 pct lower - Xinhua
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