Continuous Manufacturing of Liposomal Products
DIANT Phar
Image Credit: InProcess
Continuous manufacturing is starting to gain increased interest over traditional batch processing for nanoparticle drug delivery systems. DIANT Pharma Inc. (DIANT) provides a turnkey solution for the continuous processing of nanoparticles by offering multiple modules and integrated process analytical technology as a single closed-system.
Inventors of the Continuous Manufacturing System
DIANT is a startup co-founded by Antonio Costa, Ph.D. and Diane Burgess, Ph.D. In 2020, DIANT licensed their core manufacturing technology from UConn and was granted a patent on the technology earlier that year, with Burgess and Costa listed as inventors.
North America (United States, Canada and Mexico)
Europe (Germany, France, UK, Russia and Italy)
Asia-Pacific (China, Japan, Korea, India and Southeast Asia)
South America (Brazil, Argentina, Colombia etc.)
Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)
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Analyze and research the Process Analytical Technology (PAT) Market status and future forecast, involving capacity, value, consumption, growth rate, historical, Present and forecast.
Analysis of the geographically regions market potential and advantage, opportunity and challenge, restraints and risks.
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Monitoring Pharmaceutical Solvent Drying Processes
Image Credit: Thermo Fisher Scientific – Environmental and Process Monitoring Instruments
In a number of pharmaceutical processes, one of the key stages is the partial or complete removal of a solvent, or solvents, from an intermediate or product. The drying process needed can happen in a number of process vessels, including tray dryers, vacuum dryers, and rotary dryers.
The success of the drying process was measured upon conclusion by simply taking a sample for laboratory analysis until now.
Organic solvent concentrations in the active pharmaceutical ingredient (API), or intermediate, were measured by gas chromatography; residual water levels were usually investigated by carrying out a Karl Fischer titration.
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Real-time Characterization Of Mammalian Cell Culture Bioprocesses By Magnetic Sector MS
By Patrick Floris, a Noemí Dorival-García, Graham Lewis, Graham Josland, Daniel Merrimanb and Jonathan Bones
The complexity of mammalian cell culture processes for biopharmaceutical manufacturing has resulted in the rapid development of Process Analytical Technology (PAT) tools aimed at improving batch-to-batch reproducibility through the implementation of real-time process monitoring techniques. In particular, on-line platforms can provide rapid access to key performance indicators (KPIs) and critical process parameters (CPPs) which can assist the operator s decision-making process and facilitate the timely implementation of required corrective actions.
In this paper mammalian cell culture processes were characterized upon the analysis of the exhaust-gas composition achieved through the on-line integration of a magnetic sector MS analyser with benchtop bioreactors. The non-invasive configura