MIT s Sloan School and Computer Science and Artificial Intelligence Lab researchers together with leading pharma data scientists use crowdsourcing to better forecast drug approvals prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.
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Credit: BBVA Foundation
The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), for identifying the receptors that enable us to sense temperature, pain and pressure. Temperature, pain and pressure are part of our sense of touch, perhaps the least understood of the five main senses of humans, read the opening words of the citation. Julius and Patapoutian provided a molecular and neural basis for thermosensation and mechanosensation.
This line of research holds out exciting medical possibilities, because it sheds light on how to reduce chronic and acute pain associated with a range of diseases, trauma and their treatments. In fact, several pharmaceutical laboratories are working to identify molecules that act on these receptors with the aim of treating different fo
Circadian clock shows Junk DNA plays key role sandiegosun.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sandiegosun.com Daily Mail and Mail on Sunday newspapers.
‘Junk DNA’ plays a key role in regulating circadian clocks
January 7, 2021USC
Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes.
If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes.
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‘Junk DNA’ plays a key role in regulating our circadian clocks
If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes.
Until now, that research has focused on what is known as clock genes, which encode proteins that drive oscillating cycles of gene expression affecting physiology and behavior. But research just published in the Proceedings of the National Academy of Sciences reveals the discovery of a new cog in the circadian clock a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs).