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Study finds beefy good cholesterol may increase heart attack risk

Health experts have long advised their patients to make dietary changes that reduce their LDL ‘bad’ cholesterol while increasing their HDL ‘good’ cholesterol. However, studies have shown a bit of paradox in the sense that raising HDL cholesterol doesn’t necessarily reduce heart disease risk and the reason, according to the latest research, may be problems associated with big versus small cholesterol particles. Put simply, ‘bad’ LDL cholesterol is the kind that causes a build-up in the arteries, putting someone at risk of heart disease and related issues. ‘Good’ HDL cholesterol, meanwhile, shuttles cholesterol from the arteries to the liver for elimination.

Robert elosuaHospital del mar medical research instituteHospital del mar medical researchமருத்துவமனை டெல் மார் மருத்துவ ஆராய்ச்சி நிறுவனம்மருத்துவமனை டெல் மார் மருத்துவ ஆராய்ச்சி

Study reveals not all good cholesterol is healthy

Study reveals not all good cholesterol is healthy
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United statesBaja californiaRobert elosuaAlvaro hernaezClinico universitarioAlbert pratsPublic healthCardiovascular genetics research groupUniversity of vic central catalonia uvicHospital del mar medical research instituteCardiovascular diseasesHospital clinico universitarioHospital delVic central universityஒன்றுபட்டது மாநிலங்களில்பஜா கலிஃபோர்னியா

Herzinfarkt durch gesundes HDL-Cholesterin?

Herzinfarkt durch gesundes HDL-Cholesterin?
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Aleksandr stindtRobert elosuaParticipation of researchExperimental hospital del mar medical research instituteHospital del mar medical research instituteThat protectsLatest resultsParticles playDirectly linkedResult of an investigationHdl cholesterolLiver helpsCholesterinpartikel determineGreat hdl cholesterinpartikelCholesterins increaseMedical literature

Study reveals how cancer cells escape death by lymphocytes

Study reveals how cancer cells escape death by lymphocytes
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Comunidad autonoma de catalunaIsrael generalAlex martEmily hendersonBreast cancer research foundationHealth institute instituto de salud carlosNature communicationsArriba growth factors groupHospital del mar medical research instituteSpanish associationFoundation comprehensive program of cancer immunotherapy immunologyHebron institute of oncologyStudy coTranslational researchPostdoctoral fellowGraduate student

The unveiling of a novel mechanism of resistance to immunotherapy targeting HER2

E-Mail IMAGE: Joaquín Arribas, co-Program Director of Preclinical and Translational Research at VHIO, ICREA Professor, CIBERONC Investigator, Director of the Hospital del Mar Medical Research Institute (IMIM). view more Credit: VHIO Redirection of lymphocytes, via T-cell bispecific antibodies (TCBs) and chimeric antigen receptors (CARs), is already approved to treat some hematologic malignancies. In solid tumors these immune-based strategies continue to fail. Research led by Joaquín Arribas, co-Program Director of Preclinical and Translational Research at VHIO, has now shown how HER2 breast cancer cells adopt a strategy to resist clearance by redirected lymphocytes. Findings evidence that the disruption of interferon-gamma signaling confers resistance to these immunotherapies and promotes disease progression.

Comunidad autonoma de catalunaComunidad autonoma de aragonRius ruizAlex martBreast cancer research foundationHealth institute instituto de salud carlosNature communicationsArriba growth factors groupHospital del mar medical research instituteSpanish associationFoundation comprehensive program of cancer immunotherapy immunologyTranslational researchProgram directorPostdoctoral fellowGraduate studentCorresponding author