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Novel Test Detects Leftover Cancer DNA in the Blood by Angela Mohan on April 30, 2021 at 2:59 PM
Tumor-uninformed test detects the residual or leftover cancer DNA circulating in the blood of patients following treatment.
Guardant Reveal test developed by precision oncology company Guardant Health, is tumor-uninformed . It doesn t require knowing mutations that were present in the patient s tumor. The use of ctDNA, which is a type of liquid biopsy , is a powerful prognostic tool to detect residual disease, and many prospective trials are under way in the United States, Europe, Asia and Australia to use ctDNA to guide treatment decision-making, says lead author Aparna R. Parikh, MD, an investigator in the Division of Hematology and Oncology at MGH and an assistant professor of Medicine at Harvard Medical School.
Study evaluates first tumor-uninformed ctDNA assay to detect residual cancer cells after treatment
After patients with cancer undergo surgery to remove a tumor and sometimes additional chemotherapy, tools are used to identify patients at highest risk of recurrence. Non-invasive tools to detect microscopic disease are of especially high value.
In a new study published in Clinical Cancer Research a team led by investigators at Massachusetts General Hospital (MGH) has evaluated the first tumor-uninformed test that detects cancer DNA circulating in the blood of patients following treatment.
The test, called Guardant Reveal, developed by precision oncology company Guardant Health, is tumor-uninformed because, unlike previous tests for circulating tumor DNA (ctDNA) in the blood, this test does not require knowing the particular mutations that were present in the patient s tumor.