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A New Approach to Curing HIV

A New Approach to Curing HIV
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A New Approach to Curing HIV

A New Approach to Curing HIV
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

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MHRP launches trial to evaluate IL-15 Agonist as therapy to reduce HIV reservoir

MHRP launches trial to evaluate IL-15 Agonist as therapy to reduce HIV reservoir
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Experimental therapy delays viral rebound in SHIV-infected macaques

Experimental therapy delays viral rebound in SHIV-infected macaques
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New MHRP pre-clinical SHIV remission study shows progress in delaying viral load rebound

E-Mail SILVER SPRING, Md. - A recent preclinical study by U.S. Military HIV Research Program (MHRP) researchers showed that an experimental therapy combining a TLR7 agonist and two broadly neutralizing antibodies delayed viral rebound in SHIV-infected macaques after antiretroviral therapy (ART) interruption. The experimental combination therapy consisted of TLR7 agonist GS-986 and two broadly neutralizing antibodies (bnAbs), N6-LS and PGT121, targeting different regions of the HIV envelope. The rhesus macaques were initiated on viral suppressive antiretroviral therapy 14 days post infection, a timespan from infection to treatment which mirrors what is feasible in acute HIV infection. Researchers then administered the experimental combination therapy, followed by ART pause and measured how long it took for SHIV viral load to rebound.

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