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IMAGE: Molecular interactions of the receptor blocker JNJ-31020028 (light green; nitrogen atoms highlighted in blue, oxygen atoms in red) at the human Y2 receptor (grey); pdb: 7DDZ. With seven helices, the. view more
Credit: Diagram: Dr Anette Kaiser, Leipzig University
In order for a drug to be effective at the right places in the body, it helps if scientists can predict as accurately as possible how the molecules of that drug will interact with human cells. In a joint research project, scientists from Collaborative Research Centre 1423 at Leipzig University and the Chinese Academy of Sciences in Shanghai have succeeded in elucidating such a structure, namely that of the neuropeptide Y receptor Y2 with one of its ligands. This is the first time that a molecular blueprint for this receptor is available, which will enable the development of tailor-made new drugs, for example to treat epilepsy or cardiovascular diseases. The researchers findings have now been pu
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Credit: Panagiotis Kastritis
A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published their findings in the journal
Cell Reports. They investigated a multi-enzyme complex that plays an essential role in metabolism and have discovered that it functions differently than previously thought. This will help scientists better understand certain diseases.
Enzymes are a cell s biocatalysts. They accelerate chemical reactions in the body or ensure that these reactions even take place at all. As a result, they play an extremely important role in metabolism. Individual enzymes frequently form a complex with many subunits, as in the case of the pyruvate dehydrogenase complex. It occurs in all human, animal and plant cells, as well as in fungi and even in some bacteria. It is vital for energy production in cells, explains Dr Panagiotis Kastriti
Dye-Based Nanoparticles Could be Used in New Imaging Techniques
Written by AZoNanoFeb 9 2021
In a new study, physicists and chemists from Martin Luther University (MLU) have demonstrated a new approach in which tiny nanoparticles can be equipped with dyes and how these particles could be used in novel imaging techniques.
Martin Luther University Halle-Wittenberg. Image Credit: Nia Visual/Shutterstock
The research team was also the first to fully establish the internal structure of the particles. The study results were published in the leading journal,
Angewandte Chemie International Edition.
Single-chain nanoparticles, or SCNPs, are fascinating materials for biomedical and chemical applications. These particles are produced from only a single chain of molecules that folds into a single particle, the circumference of which measures just 3 to 5 nm.
Tiny nanoparticles can be furnished with dyes and could be used for new imaging techniques, as chemists and physicists at Martin Luther University Halle-Wittenberg (MLU) show in a recent study. The researchers have also been the first to fully determine the particles internal structure. Their results were published in the renowned journal
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