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Study: Targeting glycoprotein could improve response to cancer immunotherapy
It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients.
The analysis shone a light on one that popped up repeatedly in patients and mouse models that did not respond to immune checkpoint therapy: stanniocalcin-1, a glycoprotein whose role in both tumors and immunology is largely unknown.
By following the trail from this surprising thread, a University of Michigan Rogel Cancer team uncovered how stanniocalcin-1, or STC1, works inside the cell to block a cellular eat-me signal that typically triggers the immune system to produce T cells to fight the tumor. The findings, published in
Health disparities in cancer and COVID-19 are caused by similar factors
Income level, employment, housing location, medical insurance, education, tobacco and alcohol use, diet and obesity, access to medical care. These are some of the factors causing worse cancer outcomes in people who are Black.
The same factors are also causing worse outcomes from COVID-19 in this population. The similarities between COVID-19 issues and cancer disparities is uncanny, says John M. Carethers, M.D., John G. Searle Professor and Chair of Internal Medicine at Michigan Medicine. In cancer we are seeing in slow motion what has been observed rapidly with COVID - that the same conditions in our society put specific groups at risk for both. If we can fundamentally change socioeconomic inequality, we theoretically could reduce disparities in both diseases, says Carethers, who is a member of the University of Michigan Rogel Cancer Center.
Credit: Michigan Medicine
ANN ARBOR, Michigan Income level, employment, housing location, medical insurance, education, tobacco and alcohol use, diet and obesity, access to medical care. These are some of the factors causing worse cancer outcomes in people who are Black.
The same factors are also causing worse outcomes from COVID-19 in this population. The similarities between COVID-19 issues and cancer disparities is uncanny, says John M. Carethers, M.D., John G. Searle Professor and Chair of Internal Medicine at Michigan Medicine. In cancer we are seeing in slow motion what has been observed rapidly with COVID - that the same conditions in our society put specific groups at risk for both. If we can fundamentally change socioeconomic inequality, we theoretically could reduce disparities in both diseases, says Carethers, who is a member of the University of Michigan Rogel Cancer Center.
December 10, 2020 Physicians often missed key side effects of radiation therapy in patients with breast cancer who participated in a new study being presented at the 2020 San Antonio Breast Cancer Symposium. Common side effects missed by physicians included pain, itchy skin, swelling, and fatigue. Dr. Reshma Jagsi, PhD. Image courtesy of University of Michigan Rogel Cancer Center.
The findings come from researching the experiences of nearly 10,000 patients who visited dozens of practices in Michigan. The patients had all received radiation therapy following lumpectomy and noted their side effects on standard symptom reporting tools, according to presenter Dr. Reshma Jagsi, PhD, deputy chair of radiation oncology at Michigan Medicine in Ann Arbor.