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South African variant yet more concerning

South African variant yet more concerning Study on AstraZeneca vaccine’s efficacy against B.1.351 shows “disappointing” results. Geoff Caddick / AFP / Getty Images Early in February, the South African government suspended the AstraZeneca vaccine rollout after a small-scale trial found that the vaccine’s efficacy against the coronavirus variant (B.1.351) first identified in South Africa was highly reduced. Now, a new study, published today in  NEJM, found that the AstraZeneca vaccine might offer as little as 10% protection from developing mild to moderate COVID-19 infection caused by the South African variant. Scientists conducted a double-blind, placebo-controlled trial across multiple hospitals in South Africa to assess the AstraZeneca vaccine’s efficacy. Participants were randomly divided into two groups and administered two doses of either the vaccine or placebo.

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