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 E-Mail NEW YORK, NY (Feb. 1, 2021) Errors in the way chromosomes are packed into antibody-producing B cells appear to play a role in the development of B cell-related blood cancers, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons. The findings could lead to new biomarkers for predicting the onset of these cancers and to a new class of cancer therapies that prevent or correct harmful changes in genome architecture. The study was published online Feb. 1 in the journal Nature Genetics. Antibodies are made by immune cells called B cells through a series of carefully controlled chromosome rearrangements and good mutations that allow the cell to make a wide array of different antibodies. Although these changes are essential for generating the vast diversity of antibodies, there is a risk that bad mutations will occur and lead to B cell-derived cancers, says study leader Uttiya Basu, PhD, professor of microbiology & imm

New yorkUnited statesMailman school of public healthSouth koreaCholla buktoArisn economides regeneronUttiya basuColumbia university irving medical centerRegeneron pharmaceuticalsVagelos college of physiciansYiyun chen hong kong university of sciencePershing square sohn cancer research allianceLeukemia lymphoma societyJiguang wang hong kong university of scienceSchool of artsJeonbuk national university