The National Institute on Aging (NIA), part of the National Institutes of Health, has awarded a $5 million grant to researchers at University of California San Diego School of Medicine to conduct a first-in-human Phase 1 clinical trial of a gene therapy for treating Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.
First Clinical Trial to Assess Alzheimer’s Gene Therapy Receives $5 Million
News release
The National Institute on Aging (NIA), part of the National Institutes of Health, has awarded a $5 million grant to researchers at University of California San Diego School of Medicine to conduct a first-in-human Phase 1 clinical trial of a gene therapy for treating Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.
Gene therapy is an experimental technique that uses genes or gene products to treat or prevent disease instead of relying on drugs or surgery.
The clinical trial, developed by principal investigator Mark Tuszynski, MD, PhD, professor of neuroscience and director of the Translational Neuroscience Institute at UC San Diego School of Medicine, delivers the brain-derived neurotrophic factor (BDNF) gene into the brains of qualifying trial participants where it is hoped it will prompt production of BDNF in nearby cel
First-in-Human Clinical Trial to Assess Gene Therapy for Alzheimer’s Disease UC San Diego researchers will inject harmless virus carrying a restorative gene into participants’ brains, where earlier animal studies suggest it may slow, prevent or reverse progression of the neurological disorder February 18, 2021 | Scott LaFee
News release
Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.
By Rebekah Gonzalez
Feb 23, 2021
The University of San Diego School of Medicine has launched a first-in-human Phase I clinical trial to test the benefits and safety of gene therapy. They are now looking for participants.
Researchers are using the trial to see if gene therapy can be used to deliver a key protein (brain-derived neurotrophic factor or BDNF) into the brains of those with Alzheimer s disease or Mild Cognitive Impairment, which often leads to dementia. We found that delivering BDNF to the part of the brain that is affected earliest in Alzheimer s disease - the entorhinal cortex and hippocampus - was able to reverse the loss of connections and to protect from ongoing cell degeneration, said
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