Engineered Immune Cells Eliminate Brain Cancer in Mice
Researchers developed a new CAR T-cell therapy that targets specific growth factor receptors in glioblastoma to eliminate brain tumors.
Brooke Dulka, PhD
May 25, 2021
In Australia’s oldest medical research institute, researchers work to cure an aggressive brain cancer known as glioblastoma. The last decade has transformed the field of cancer research; blood cancers that were once death sentences now have treatment options. But glioblastoma remains a deadly enigma.
“I realized there was hardly any research happening in brain cancer, and applying immunotherapy there was the bold and ambitious plan we set for ourselves,” said immunologist Misty Jenkins, an associate professor at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia. In a new study published in
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A new study being led by the University of Birmingham, University Hospitals Birmingham NHS Foundation Trust, and University College London aims to explore the immune response to natural COVID-19 infection and vaccination in patients with antibody def
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The FINANCIAL COVID infection in patients with antibody deficiency (COVAD) is part of a portfolio of national studies examining the immune responses in patients at high risk of COVID-19.
A new study, funded by UK Research and Innovation, aims to explore the immune response to natural COVID-19 infection and vaccination in patients with antibody deficiency. The study is being led by:
University of Birmingham
University College London.
Vulnerable patients
Immunodeficiency patients are considered vulnerable or extremely vulnerable to COVID-19 infection and have had to undertake preventative measures to minimise their risk of exposure to the virus according to UKRI.
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IMAGE: Fluorescence labelling of distinct layers of the brain. Each colour represents a different cell type within the cortex. view more
Credit: Maria Bergamasco, WEHI.
A novel approach to immunotherapy design could pave the way for new treatments for people with an aggressive form of brain cancer called glioblastoma.
Using specifically designed receptors, researchers were able to completely clear brain cancer tumours in preclinical models, using chimeric antigen receptor (CAR) T cell therapy.
Published today in
Clinical & Translational Immunology and led by Associate Professor Misty Jenkins, the research is a crucial step towards developing new immunotherapy treatments for this devastating illness.