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QIMR Berghofer scientists develop new drugs to fight COVID-19
Scientists from QIMR Berghofer Medical Research Institute in Queensland have developed two new drugs to both prevent SARS-CoV-2 infection, and also treat people who have been exposed to the virus so they do not develop severe disease.
The peptide-based drugs are now being tested in hamsters at France’s pre-clinical and clinical research facility, IDMIT, with promising early results showing they are not toxic and have few side effects. The drugs are also stable and can be stored at room temperature – which would make them easy to distribute.
The study findings have been published overnight in the prestigious journal Nature Cell Discovery.
New gene-based vaccine strategy receives grant from the Bill & Melinda Gates Foundation
The AAVCOVID vaccine program, a novel gene-based vaccine strategy that utilizes an adeno-associated virus (AAV) vector, was granted an award for up to $2.1 million from the Bill & Melinda Gates Foundation.
The grant will aid the effort to bring further preclinical validation to the AAV vaccine platform. An AAVCOVID vaccine candidate is set to enter clinical trials in 2021.
The AAVCOVID vaccine program was founded at Mass General Brigham at the outset of the pandemic.
Preliminary tests of the vaccines stability and potency at different temperatures revealed that AAVCOVID candidates remained potent and effective when stored at room temperature for up to one month. This room temperature stability and the fact AAVCOVID vaccines do not require cold-chain freezer storage, could enable this AAV-based platform to develop a vaccine for COVID-19 and other diseases for developing countries without the n
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The AAVCOVID vaccine program, a novel gene-based vaccine strategy that utilizes an adeno-associated virus (AAV) vector, was granted an award for up to $2.1 million from the Bill & Melinda Gates Foundation.
The grant will aid the effort to bring further preclinical validation to the AAV vaccine platform. An AAVCOVID vaccine candidate is set to enter clinical trials in 2021.
The AAVCOVID vaccine program was founded at Mass General Brigham at the outset of the pandemic.
Preliminary tests of the vaccines stability and potency at different temperatures revealed that AAVCOVID candidates remained potent and effective when stored at room temperature for up to one month. This room temperature stability and the fact AAVCOVID vaccines do not require cold-chain freezer storage, could enable this AAV-based platform to develop a vaccine for COVID-19 and other diseases for developing countries without the necessary cooling infrastructure some vaccines require.