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The humoral immune response was also analyzed in a second, independent validation cohort of 182 controls and 31 patients with IMID from Germany.
HealthDay News â Patients with immune-mediated inflammatory diseases (IMIDs) receiving background methotrexate have worse humoral and cellular immunogenicity to mRNA COVID-19 vaccines, according to a study published online May 25 in the
Annals of the Rheumatic Diseases.
Rebecca H. Haberman, M.D., from New York University Langone Health in New York City, and colleagues examined humoral and cellular immune responses to the BNT162b2 mRNA COVID-19 vaccine among 51 patients with IMID and 26 healthy controls from NYU Langone Health. The humoral immune response was also analyzed in a second, independent validation cohort of 182 controls and 31 patients with IMID from Germany.
Patients with lupus nephritis who received voclosporin maintained “meaningful” reductions in proteinuria, with stable mean estimated glomerular filtration rates, at 2 years, according to a poster session at the EULAR 2021 Virtual Congress.
The findings represent the first interim data from an extension of the previously reported phase 3 AURORA 1 study, which, alongside the phase 2
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Up to a third of patients taking methotrexate - a common treatment for immune mediated inflammatory conditions such as rheumatoid arthritis and psoriasis/psoriatic arthritis - failed to achieve an adequate immune response to mRNA COVID-19 vaccines in a small study accepted for publication in the journal Annals of the Rheumatic Diseases.