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Night and Day: Animal Studies May Not Translate to Humans Without Time Considerations

Most behavioral testing does not account for animals circadian rhythms, shows survey

Animal Studies May Not Translate to Humans without Time Considerations

Like night and day: Animal studies may not translate to humans without time considerations

 E-Mail IMAGE: In a recent survey of published animal studies, Randy Nelson chair of the WVU Department of Neuroscience and director of basic science research for the Rockefeller Neuroscience Institute . view more  Credit: WVU Photo/Jennifer Shephard MORGANTOWN, W.Va. Imagine being woken up at 3 a.m. to navigate a corn maze, memorize 20 items on a shopping list or pass your driver s test. According to a new analysis out of West Virginia University, that s often what it s like to be a rodent in a biomedical study. Mice and rats, which make up the vast majority of animal models, are nocturnal. Yet a survey of animal studies across eight behavioral neuroscience domains showed that most behavioral testing is conducted during the day, when the rodents would normally be at rest.

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