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Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer. Using this protein as a target, the team successfully created a CAR T cell therapy - a type of immunotherapy - that killed pancreatic cancer cells in a pre-clinical model.
CAR T cell therapy is an immunotherapy that has shown great promise for the treatment of some blood cancers; however, the treatment of solid tumours using this therapy has proved very difficult. One barrier to success is toxicity in tissues other than the cancer because most of the proteins currently used to target CAR T cells to pancreatic cancer cells and other solid tumours are present in low levels on other normal tissues, leading to toxic side effects.
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Patients of Asian and black backgrounds suffered disproportionate rates of premature death from COVID-19, according to a study of 1,737 patients by Queen Mary University of London and Barts Health NHS Trust.
The study, published in
BMJ Open, is one of the most comprehensive studies exploring COVID-19 outcomes in black, Asian and minority ethnic populations so far reported, from one of the largest and most diverse UK hospital COVID-19 cohorts, representing a majority ethnically diverse population (only 35.2 per cent of patients identified as White ethnicity).
The work resulted from a new interdisciplinary collaboration between intensive care physicians and HIV physicians. The researchers looked at data from all patients aged 16 years or over with confirmed SARS-CoV-2 infection and admitted to the five acute hospitals within Barts Health NHS Trust, between 1 January and 13 May 2020.
The Company enables its partners to optimise their customers digital ecosystem to increase productivity and enhance brand experiences through Human Experience Management.
Developed from 10 years of patented academic research and three patents, the Company s Human Experience Management Services analyse the human experience of any digital service. The Company s service provides organisations with actionable information whereby changes to the digital ecosystem can be made to optimise and improve digital experience for customers and employees. For any organisation, this means that their most valuable asset - their employees - are liberated from digital slow time, their online brand reputation can be protected and they can make informed ecosystem investment decisions.
Launch of Placing via Accelerated Bookbuild Actual Experience plc (AIM: ACT), the analytics-as-a-service company, announces its intention to raise gross proceeds of £10.0 million by means of a placing to institutional investors (the Placing ), of new ordinary shares of 0.2 pence each in the Company (the Placing Shares ), at a price of no less than 105.0 pence per share ( Issue Price ). The minimum Issue Price is at a discount of approximately 13.9 per cent. to the mid-market closing price of an existing ordinary share of 122.0 pence on 20 January 2021, the last practicable date prior to the date of this Announcement. Nplus1 Singer Capital Markets Limited (together with its associates, N+1 Singer ) is acting as nominated adviser, sole bookrunner and sole broker in connection with the Placing.
ICC Victims Fund: Who’s responsible for its failure? (Everybody)
ICC TRUST FUND SERIES - EPISODE 5
As shown in previous articles, the International Criminal Court’s Trust Fund for Victims has not delivered on its mandate. By 2020, less than 300 victims have received reparations in only one ICC case. Who is to be blamed? The Fund’s management? Their staff? Its Board? The judges? States? NGOs? No one is spared.
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