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Building on their previous findings, scientists from the Immuno-Pharmacology and Interactomics group at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), a nonprofit research institute, have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain.

Andy chevignOjas namjoshiMartyna szpakowskaMarkus ollertEmily hendersonMinistry of higher educationDepartment of infectionNature communicationsImmunity of the luxembourg institute healthEuropean commissionLuxembourg national research fundLuxembourg instituteDrug discoverySignal transductionTargeted therapyProf markus ollert