Scientists develop an enhanced version of phototoxic protein
Scientists from Skoltech, the Institute of Bioorganic Chemistry of RAS, and the London Institute of Medical Sciences (LMS) have developed an enhanced version of SuperNova, a genetically encoded phototoxic synthesizer, that helps control intracellular processes by light exposure. The research was published in the
International Journal of Molecular Sciences.
An important research tool, phototoxic proteins are used as genetically encoded photosensitizers to generate reactive oxygen species under light irradiation. In contrast to common chemical photosensitizers, phototoxic proteins are genetically encoded and expressed by the cell itself, which makes them easy to control and direct to any selected compartment in the cell. Thanks to reactive oxygen species formed by the action of light, phototoxic proteins can create strictly localized oxidative stress, for example, to destroy a selected cell population or disable target pr
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IMAGE: A single mutation S10R with the replacement of serine at position 10 for arginine (highlighted in blue on the protein structure on the left), despite its removal from the chromophore. view more
Credit: Skoltech
Scientists from Skoltech, the Institute of Bioorganic Chemistry of RAS, and the London Institute of Medical Sciences (LMS) have developed an enhanced version of SuperNova, a genetically encoded phototoxic synthesizer, that helps control intracellular processes by light exposure. The research was published in the
International Journal of Molecular Sciences.
An important research tool, phototoxic proteins are used as genetically encoded photosensitizers to generate reactive oxygen species under light irradiation. In contrast to common chemical photosensitizers, phototoxic proteins are genetically encoded and expressed by the cell itself, which makes them easy to control and direct to any selected compartment in the cell. Thanks to reactive oxygen