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What Breakthrough Infections Can Tell Us Katherine J. Wu © Lisa Maree Williams/Getty With 165 million people and counting inoculated in the United States, vaccines have, at long last, tamped the pandemic’s blaze down to a relative smolder in this part of the world. But the protection that vaccines offer is more like a coat of flame retardant than an impenetrable firewall. SARS-CoV-2 can, very rarely, still set up shop in people who are more than two weeks out from their last COVID-19 shot. These rare breakthroughs, as I’ve written before, are no cause for alarm. For starters, they’re fundamentally different from the infections we dealt with during the pre-mass-vaccination era. The people who experience them are getting less sick, for shorter periods of time; they are harboring less of the coronavirus, and spreading fewer particles to others. Breakthroughs are also expected, even unextraordinary. They will be with us for as long as the coronavirus is and e

New yorkUnited statesTom clarkLisa maree williams gettyKristen ehresmannStephanie meyerKelly wroblewskiJay varmaSaskia popescuRobin patelBryan mcnamaraMinnesota department of healthUniversity of north carolina at chapel hillInfectious diseases research laboratory at mayo clinicAssociation of public health laboratoriesUniversity of arizona