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CHAPEL HILL, NC - Many molecules in our bodies help our immune system keep us healthy without overreacting so much that our immune cells cause problems, such as autoimmune diseases. One molecule, called AIM2, is part of our innate immunity - a defense system established since birth - to fight pathogens and keep us healthy. But little was known about AIM2 s contribution to T cell adaptive immunity - defenses developed in response to particular pathogens and health problems we develop over the course of our lives.
Now, UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that occurs in
Study Suggests Way to Boost Immunotherapy Against Breast Cancer, Other Solid Tumors pharmacytimes.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from pharmacytimes.com Daily Mail and Mail on Sunday newspapers.
Solid tumors, such as breast cancers can be targeted by boosting our immune system T cells via the addition of a small molecule to the treatment procedure called chimeric antigen receptor-T (CAR-T) cell therapy.
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IMAGE: UNC Lineberger Comprehensive Cancer Center s Jonathan S. Serody, MD, and colleagues report that adding a small molecule to a chimeric antigen receptor-T (CAR-T) cell therapy can help immune system T. view more
Credit: UNC Lineberger Comprehensive Cancer Center
CHAPEL HILL, NC Boosting immune system T cells to effectively attack solid tumors, such as breast cancers, can be done by adding a small molecule to a treatment procedure called chimeric antigen receptor-T (CAR-T) cell therapy, according to a study by researchers at the UNC Lineberger Comprehensive Cancer Center. The boost helps recruit more immune cells into battle at the tumor site. The findings are published in the
Steven Eugene Oldham sanfordherald.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sanfordherald.com Daily Mail and Mail on Sunday newspapers.