MAY 24, 2021, NEW YORK - A Ludwig Cancer Research study has discovered how to revive a powerful but functionally inert subset of anti-cancer immune cells.
Pancreatic cancer cells de-differentiate to spawn highly aggressive tumors, study shows
A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert-or de-differentiate -to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes.
The study, led by Ludwig Lausanne s Douglas Hanahan and published in
Cancer Discovery, a journal of the American Association for Cancer Research, also shows that engagement of the mechanism is associated with poorer outcomes in patients diagnosed with pancreatic neuroendocrine tumors (PanNETs). Further, its findings provide concrete evidence that such cellular de-differentiation, widely observed across cancer types, is a not merely a random consequence of cancer cells other aberrations.
Credit: Ludwig Cancer Research
APRIL 28, 2021, NEW YORK - A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert or de-differentiate to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes.
The study, led by Ludwig Lausanne s Douglas Hanahan and published in
Cancer Discovery, a journal of the American Association for Cancer Research, also shows that engagement of the mechanism is associated with poorer outcomes in patients diagnosed with pancreatic neuroendocrine tumors (PanNETs). Further, its findings provide concrete evidence that such cellular de-differentiation, widely observed across cancer types, is a not merely a random consequence of cancer cells other aberrations.
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Ludwig Cancer Research study shows pancreatic cancer cells hit reverse to advance in malignancy
APRIL 28, 2021, NEW YORK – A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert-or “de-differentiate”-to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes.
The study, led by Ludwig Lausanne’s Douglas Hanahan and published in Cancer Discovery, a journal of the American Association for Cancer Research, also shows that engagement of the mechanism is associated with poorer outcomes in patients diagnosed with pancreatic neuroendocrine tumors (PanNETs). Further, its findings provide concrete evidence that such cellular de-differentiation, widely observed across cancer types, is a not merely a random consequence of cancer cells’ other aberrations.
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Ludwig Princeton’s Eileen White and Ludwig Harvard’s Alan D’Andrea elected to National Academy of Sciences
APRIL 28, 2021, NEW YORK – Ludwig Cancer Research congratulates Ludwig Princeton Associate Director Eileen White and Ludwig Harvard investigator Alan D’Andrea on their election to the National Academy of Sciences. They are among 120 newly elected members and 30 international members elected to the Academy this year-a rare honor now bestowed on just 2,972 scientists worldwide for singular contributions to their fields of research.
The National Academy of Sciences (NAS) is a private, nonprofit institution established under a congressional charter signed by President Abraham Lincoln in 1863. Together with the National Academy of Engineering, Institute of Medicine and National Research Council, the NAS provides independent advice on issues related to science and technology to the federal government and other organizations.