How teenagers are coping in the COVID-19 pandemic
This was supposed to be their time to launch into the world, but then the world closed down. Some teens have been resilient, but others have had worsening mental-health problems – and the long-term effects on their lives may not be clear for a long time Bookmark Please log in to listen to this story. Also available in French and Mandarin. Log In Create Free Account
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Fred Lum/The Globe and Mail
For almost 12 months now, Canada’s teenagers have essentially been locked up with their parents. By the time the pandemic ends, two sets of graduations and proms will have been cancelled, along with a year and a half of sports tournaments, school plays, movies, dates and parties – basically, everything they’d been promised would make the final years of high school the best of their vanishing childhoo
امریکا میں دریافت ہونے والی کورونا وائرس کی نئی قسم دنیا میں تیزی سے پھیلنے لگی - Health dawnnews.tv - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dawnnews.tv Daily Mail and Mail on Sunday newspapers.
The COVID-19 pandemic caused by the SARS-CoV-2 virus continually poses serious threats to global public health. The main protease (Mpro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing Mpro inhibitors derived from either Boceprevir or Telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 Mpro activity in vitro with IC50 values ranging from 7.6 to 748.5 nM. The co-crystal structure of Mpro in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a SARS-CoV-2 infection transgenic mouse model, oral or intraperitoneal treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats.
Feb 17, 2021
Preprint findings outline the woes of SARS-CoV-2 viral mutations
Results from a preprint study identified seven Covid-19 variants that seem to have originated in the United States and it’s possible these mutant strains are even more contagious, the study authors warned.
In their study, which was published in
MedRxiv and is not yet peer-reviewed, Jeremy P. Kamil, PhD, of the Louisiana State University Health Sciences Center in Shreveport, Louisiana, and colleagues discovered that all seven variants carry the same mutation to amino acid position 677 a convergent adaptation that may signal an evolutionary advantage for these strains. And, while it is not clear yet whether this particular mutation makes these strains more contagious, the study authors have their suspicions.