People who experience big dips in blood sugar levels consume more calories
New research shows that people who experience big dips in blood sugar levels, several hours after eating, end up feeling hungrier and consuming hundreds more calories during the day than others.
A study published today in
Nature Metabolism, from PREDICT, the largest ongoing nutritional research program in the world that looks at responses to food in real life settings, the research team from King s College London and health science company ZOE (including scientists from Harvard Medical School, Harvard T.H. Chan School of Public Health, Massachusetts General Hospital, the University of Nottingham, Leeds University, and Lund University in Sweden) found why some people struggle to lose weight, even on calorie-controlled diets, and highlight the importance of understanding personal metabolism when it comes to diet and health.
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Ludwig Cancer Research scientists to present advances in immunotherapy, cancer metabolism
APRIL 10, 2021, NEW YORK – Ludwig Cancer Research released today the full scope of research to be presented by Ludwig-affiliated scientists at the April 9-14 American Association for Cancer Research (AACR) Annual Meeting, the first of two meetings which will be held online this year.
“The AACR Annual Meeting has long served as major opportunity for cancer researchers at all stages of their careers and from all over the world to meet, exchange ideas and forge collaborations to advance the study and treatment of cancer,” said Chi Van Dang, scientific director of the Ludwig Institute for Cancer Research and Editor-in-Chief of AACR’s Cancer Research journal. “The COVID-19 pandemic may have disrupted the physical gathering, but the intellectual exchange it enables will continue unimpeded. Ludwig and its scientists are excited about participating in that exchange.”
Targeting microRNAs makes cancer stem cells more susceptible to chemotherapies
Researchers in Italy have identified a pair of microRNA molecules that help maintain a population of cancerous stem cells that drive the growth of breast cancers and initiate tumor relapse after treatment. The study, which will be published April 2 in the
Journal of Cell Biology (
JCB), reveals that targeting these microRNAs makes cancer stem cells more susceptible to some chemotherapies and could potentially improve the prognosis of patients with aggressive forms of breast cancer.
Many tumors contain a small population of cancer stem cells that initiate tumor growth and give rise to the various cell types found in tumors. Moreover, because cancer stem cells are often resistant to radio- and chemotherapies, they can survive and promote tumor relapse and metastasis after initial rounds of treatment. In breast cancer, for example, tumors containing a relatively high number of cancer stem cells have a mu
HCAs are a promising risk indicator of type 2 diabetes
A series of studies led by researchers from Hong Kong Baptist University (HKBU) have revealed that hyocholic acid and its derivatives (collectively known as HCAs), a component of bile acids that facilitate fat digestion, are a promising risk indicator of type 2 diabetes. The strong efficacy of HCAs in regulating blood glucose levels and protecting against diabetes has also been uncovered. The findings open a window for the development of HCA-based predictive markers as well as anti-diabetic drugs.
The research results have been published in the international scientific journals
Cell Metabolism and
Diet and lifestyle may play a significant role in Alzheimer s disease
For years, research to pin down the underlying cause of Alzheimer s Disease has been focused on plaque found to be building up in the brain in AD patients. But treatments targeted at breaking down that buildup have been ineffective in restoring cognitive function, suggesting that the buildup may be a side effect of AD and not the cause itself.
A new study led by a team of Brigham Young University researchers finds novel cellular-level support for an alternate theory that is growing in strength: Alzheimer s could actually be a result of metabolic dysfunction in the brain. In other words, there is growing evidence that diet and lifestyle are at the heart of Alzheimer s Disease.