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International study finds increased COVID-19 mortality among adults with Down syndrome

 E-Mail A new study by an international team of researchers found that adults with Down syndrome are more likely to die from COVID-19 than the general population, supporting the need to prioritize vaccinating people with the genetic disorder. Investigators found that adults with Down syndrome were roughly three times more likely to die from COVID-19 than the general population. This increased risk was especially apparent in from fifth decade of life: A 40-year-old with Down syndrome had a similar risk of dying from COVID-19 as someone 30 years older in the general population. The study was published this week in The Lancet s

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body s glucose levels, which is important for the development of metabolic diseases like diabetes. In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat. In the study, Mukesh K. Jain, MD, senior author, Chief Academic Officer at UH, and the Ellery Sedgwick Jr. Chair & Distinguished Scientist, and his team set out to investigate the role of a gene called Kruppel-like factor 15 (KLF15) in skeletal muscle. The team utilized a mouse model with KLF15 specifically deleted in musc

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