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Nitrous oxide, also known as laughing gas, has shown promise as a treatment for depression. When people inhaled a low dose as part of a small study, their depression improved over the next two weeks.
It has long been known that nitrous oxide can give a short boost to mood as well as relieving pain – hence its original name of laughing gas – but the effect is thought to wear off quickly. Nitrous oxide is one of the most common anaesthetics, used by hospitals, dental surgeries and paramedics, as well as being available illegally in small capsules for recreational use.
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IMAGE: Peter Nagele, M.D., professor and chair of the Department of Anesthesia & Critical Care at the University of Chicago, hasbeen studying the potential of nitrous oxide as an antidepressant for. view more
Credit: University of Chicago
A single, one-hour treatment that involves breathing in a mixture of oxygen and nitrous oxide otherwise known as laughing gas significantly improved symptoms in people with treatment-resistant depression, according to new data from researchers at Washington University School of Medicine in St. Louis and the University of Chicago.
In a phase 2 clinical trial, the researchers demonstrated that symptoms of depression improve rapidly following treatment with inhaled nitrous oxide. Further, they reported the benefits can last for several weeks.
Targeted therapy shrank tumors, shows promise in improving survival
June 4, 2021 SHARE
Medical oncologist and senior author of a new lung cancer study, Ramaswamy Govindan, MD, of Washington University School of Medicine in St. Louis, talks about the newly FDA-approved drug sotorasib. The new study shows that sotorasib benefits some patients who have non-small-cell lung cancer that has a specific mutation in the KRAS gene. Ongoing clinical trials for lung cancer patients are investigating combinations of sotorasib plus other experimental drugs. (Video: Huy Mach/School of Medicine)
The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients with lung adenocarcinoma, a common type of non-small-cell lung cancer.
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