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Western diet may increase risk of gut inflammation, infection
IMAGE: A tiny, 3D model of the intestines formed from anti-inflammatory cells known as Paneth cells (green and red) and other intestinal cells (blue) is seen in the image above. Researchers.
Image:
Ta-Chiang Liu
Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.
The study, in mice and people, showed that a diet high in sugar and fat causes damage to Paneth cells, immune cells in the gut that help keep inflammation in check. When Paneth cells aren t functioning properly, the gut immune system is excessively prone to inflammation, putting people at risk of inflammatory bowel disease and undermining effective control of disease-causing microbes. The findings, published May 18 in
Western diet, not high BMI, may fuel irritable bowel disease
Eating a typical Western diet, which is high in sugar and fat, may cause major changes to gut immune cells that pave the way for irritable bowel disease (IBD), a chronic condition that can be painful and have a negative effect on one’s life. The study involved mice, including some with genetic mutations that caused them to overeat.
The Western diet is commonly high in salt, sugar, and fat, with excessive meat consumption and too much processed foods. This diet’s potential impact on health has been studied extensively and associated with things like increased risk of cancer and heart disease. The same diet may also put one at risk of developing IBD.
When the Centers for Disease Control and Prevention made an abrupt change to its guidance Thursday, stating that fully vaccinated people could stop wearing masks in most settings, it was welcomed, if not whiplash-inducing, news.
Vaccination is going relatively well in this country, although the number of people who receive a dose each day is down from its peak. And new cases, hospitalizations and deaths from the virus are decreasing.
Things could always get bad again, and the CDC could always update its guidance and reintroduce more aggressive restrictions. But right now, this moment feels to many like the beginning of the end of the pandemic. Still, even after the virus is brought under control it is still likely to have lingering effects. This is the long tail of COVID-19.
Diet rich in sugar, fat damages immune cells in digestive tracts of mice
May 18, 2021 SHARE A tiny, 3D model of the intestines formed from anti-inflammatory cells known as Paneth cells (green and red) and other intestinal cells (blue) is seen in the image above. Researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic used such models, called organoids, to understand why a Western-style diet rich in fat and sugar damages Paneth cells and disrupts the gut immune system. (Image: Ta-Chiang Liu)
Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.
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