Promising role for whole genome sequencing in guiding blood cancer treatment – Washington University School of Medicine in St Louis wustl.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from wustl.edu Daily Mail and Mail on Sunday newspapers.
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IMAGE: A new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that. view more
Credit: ERIC DUNCAVAGE
For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes. Some of these tests rely on technology that was invented more than 60 years ago and has been used clinically for the past three decades.
Now, a new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing. In addi
New study may lead to therapeutic strategies for chronic lung disease
Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection.
The evidence suggests that activation of this immune cell a type of guardian cell called a dendritic cell serves as an early switch that, when activated, sets in motion a chain of events that drives progressive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
The new study, published in The
Journal of Immunology, opens the door to potential preventive or therapeutic strategies for chronic lung disease. More immediately, measuring the levels of these dendritic cells in clinical samples from patients hospitalized with a viral infection, such as influenza or COVID-19, could help doctors identify which patients are at high risk of respiratory failure and death.
Updated: 1:30 PM CST March 10, 2021
ST. LOUIS In what’s sure to be music to audiences’ ears, the St. Louis Symphony Orchestra announced it will resume live, socially distanced concerts at Powell Hall for the spring season, March 26-May 15.
Tickets for live, in-person concerts are now on sale to the public, the SLSO and Music Director Stéphane Denève announced Tuesday. Capacity will be limited to 300 people at live concerts. Each show will be about an hour and without intermission.
The spring 2021 live events will consist of eight weeks of performances at Powell Hall, led by Denève, conductor laureate Leonard Slatkin and SLSO assistant conductor Stephanie Childress, who begins her tenure as music director of the St. Louis Symphony Youth Orchestra.
A new study provides evidence that COVID-19 patients’ heart damage results from the virus invading and replicating inside heart muscle cells, leading to cell death and interfering with heart muscle contraction.
The researchers used stem cells to engineer heart tissue that models the human infection and could help in studying the disease and developing possible therapies.
“Early on in the pandemic, we had evidence that this coronavirus can cause heart failure or cardiac injury in generally healthy people, which was alarming to the cardiology community,” says senior author Kory J. Lavine, associate professor of medicine at Washington University School of Medicine in St. Louis.